谷胱甘肽单乙基酯对小鼠体内GSH含量的影响  

Influcncs of Glutathione Monoethyl Ester on GSH Level in Mice

作　　者：郑全美[1] 皮静波[1] 刘宣军 吕秀强[1] 龚丽霞[1] 

机构地区：[1]中国医科大学,沈阳医学院

出　　处：《中国公共卫生学报》1996年第4期218-219,共2页

摘　　要：为探讨谷胱甘肽单乙基酯（ＧＥ）对体内还原型谷胱甘肽（ＧＳＨ）含量的影响，给予小鼠腹腔注射ＧＥ和ＧＳＨ，观察给药后不同时间小鼠全血、肝脏及肾脏内ＧＳＨ水平．结果表明：ＧＳＨ和ＧＥ均能提高全血、肝脏及肾脏内ＧＳＨ水平，但外源性ＧＳＨ作用时间很短，效率较低，而ＧＥ可使肝脏和肾脏内ＧＳＨ较长时间维持在较高水平．提示ＧＥ能够比ＧＳＨ更有效地提高机体ＧＳＨ水平．Female mice were administered intraperitoneally with glutathione monoethyl eater(GE) and extraneous glutathione to study their influences on glutathione(GSH) lever in body.GSH concentrationg of blood、liver and kidney were measured after administered 0、5、10、30、60、120、240、480min.The results showed: although the GSH level in blood、liver and kidney were both enhanced by extraneous glutathione and GE, but the effect of extraneous glutathione was very short and efficiency was also low. GE could maintain high GSH level in liver and kidney for a long time.GE was much more efficient than extraneous GSH to increased GSH level in body.

关 键 词：谷胱甘肽 单乙基酯 GE 小鼠 毒理 

分 类 号：R992[医药卫生—毒理学]