One-pot Synthesis of lO-Methyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-l,8-dione Derivatives under Microwave Heating without Catalyst  

作　　者：华国平 章晓镜 石枫 屠树江 徐佳宁 王倩 朱晓彤 张金鹏 纪顺俊 

机构地区：[1]Xuzhou Institute of Architectural Technology, Xuzhou, Jiangsu 221008, China [2]Key Laboratory of Biotechnology for Medicinal Plants, Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China [3]Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou, Jiangsu 215006, China

出　　处：《Chinese Journal of Chemistry》2005年第12期1646-1650,共5页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20372057） and the Natural Science Foundation of Jiangsu Province （No. BK2001142）.

摘　　要：A series of 10-methyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione derivatives were synthesized by one-pot reaction of aldehyde, dimedone or 1,3-cyclohexanedione and methylamine in glycol or water under microwave heating without catalyst. The method has the advantage of short routine and reaction time, high yields as well as friendly environment. And the reaction was not only suitable for aliphatic and aromatic monoaldehyde, but also for aromatic dialdehyde.A series of 10-methyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione derivatives were synthesized by one-pot reaction of aldehyde, dimedone or 1,3-cyclohexanedione and methylamine in glycol or water under microwave heating without catalyst. The method has the advantage of short routine and reaction time, high yields as well as friendly environment. And the reaction was not only suitable for aliphatic and aromatic monoaldehyde, but also for aromatic dialdehyde.

关 键 词：ALDEHYDE DIMEDONE 1 3-CYCLOHEXANEDIONE METHYLAMINE 10-methyl-1 2 3 4 5 6 7 8 9 10-decahydroacridine-1 8-dione microwave heating 

分 类 号：O622.4[理学—有机化学]