Synthesis and Determination of Absolute Configuration of a Divergent Polyhydroxy Enyne Compound  

作　　者：Zhi Jie XUE Yuan Chao LI 

机构地区：[1]Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203

出　　处：《Chinese Chemical Letters》2005年第12期1569-1572,共4页中国化学快报（英文版）

摘　　要：Polyhydroxy enyne compound （＋）-（1＇S, 2R, 3S, 5S, 6S）-5,6-dimethoxy-5, 6-dimethyl- 2-（1＇-hydroxylpropyl-2-ne）-3-vinyl-l,4-dioxane has been synthesized from D-（-）-tartaric acid. A new chiral center was established by nucleophilic addition with 87% de. The modified Mosher＇s method was employed to confirm the absolute configuration of 17, which assigned the S-configuration at the new chiral center.Polyhydroxy enyne compound （＋）-（1＇S, 2R, 3S, 5S, 6S）-5,6-dimethoxy-5, 6-dimethyl- 2-（1＇-hydroxylpropyl-2-ne）-3-vinyl-l,4-dioxane has been synthesized from D-（-）-tartaric acid. A new chiral center was established by nucleophilic addition with 87% de. The modified Mosher＇s method was employed to confirm the absolute configuration of 17, which assigned the S-configuration at the new chiral center.

关 键 词：Tartaric acid enyne compound nucleophilic addition modified Mosher＇s method 

分 类 号：O625.51[理学—有机化学]