Approach to N-Alkoxy-2-oxoindole for Mimicing SERMs Structure  

作　　者：Ji Cheng CHU Dong Zhi LIU Hong Sheng GUO Kang ZHAO 

机构地区：[1]School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 [2]Medical College, Chinese People＇s Armed Police Force, Tianjin 300071 [3]College of Pharmaceutical and Biotechnology, Tianjin University,Tianjin 300072

出　　处：《Chinese Chemical Letters》2005年第12期1593-1596,共4页中国化学快报（英文版）

摘　　要：Treatment of N-alkoxyamides with bis（trifluoroacetoxy）iodobenzene generated electron deficient nitrogen species, which readily cyclized onto aromatic ring to give N-alkoxy-2- oxoindoles. The effect of different substituent on aromatic ring to the electrophilic substitution was studied.Treatment of N-alkoxyamides with bis（trifluoroacetoxy）iodobenzene generated electron deficient nitrogen species, which readily cyclized onto aromatic ring to give N-alkoxy-2- oxoindoles. The effect of different substituent on aromatic ring to the electrophilic substitution was studied.

关 键 词：N-Alkoxyamides bis（trifluoroacetoxy）iodobenzene intramolecular cyclization 

分 类 号：O629[理学—有机化学]