Two New Eremophilane Sesquiterpene Lactones from Ligularia myriocephala Ling  

作　　者：Jun Xi LIU Xiao Ning WEI Yan Ping SHI Run Hua LU 

机构地区：[1]Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 [2]Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041

出　　处：《Chinese Chemical Letters》2005年第12期1618-1620,共3页中国化学快报（英文版）

基　　金：supported by the National Natural Sciences Foundation of China(No.20021001,20372029 and 20475057).

摘　　要：Two new eremophilane sesquiterpene lactones, 1β-angeloyloxy-6β, 10β-dihydroxy-8β- methoxyeremophila-7（ll）en-8α,12-olide and 1β-angeloyloxy-6β,10α-dihydroxy-8α-methoxyeremo- phila-7（ 11）en-8β, 12-olide were isolated from the extract of the whole plant of Ligularia myriocephala Ling. Their structures and stereochemistry were elucidated by various spectroscopic methods including intensive 2D-NMR techniques （COSY, gHMQC, gHMBC and ^1H-^1H NOESY） and HR-ESIMS.Two new eremophilane sesquiterpene lactones, 1β-angeloyloxy-6β, 10β-dihydroxy-8β- methoxyeremophila-7（ll）en-8α,12-olide and 1β-angeloyloxy-6β,10α-dihydroxy-8α-methoxyeremo- phila-7（ 11）en-8β, 12-olide were isolated from the extract of the whole plant of Ligularia myriocephala Ling. Their structures and stereochemistry were elucidated by various spectroscopic methods including intensive 2D-NMR techniques （COSY, gHMQC, gHMBC and ^1H-^1H NOESY） and HR-ESIMS.

关 键 词：Ligularia myriocephala Ling COMPOSITAE sesquiterpene lactones eremophilanolide 

分 类 号：O629.61[理学—有机化学]