帕罗西汀与丙咪嗪治疗抑郁症的对照研究  

A comparative study of paroxetine and imipramine in the treatment of depression

作　　者：周军[1] 徐喜云 刘玉龙[1] 

机构地区：[1]山东省济宁市荣复军人医院,山东济宁272101

出　　处：《中国民康医学》2005年第12期731-732,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:评价帕罗西汀的抗抑郁疗效及副作用。方法:对60例符合CCMD-3诊断标准的抑郁症患者,随机分为两组,分别用帕罗西汀和丙咪嗪治疗6周,用汉密尔顿抑郁量表(HAMD),汉密尔顿焦虑量表(HAMA)评定疗效,用副反'应量表(TESS)评定副反应。结果:帕罗西汀和丙咪嗪疗效相当(P>0.05),其显效率为83.33%、76.67%,帕罗西汀对伴随的焦虑症状有较好疗效,帕罗西汀不良反映较丙咪嗪少而轻微。结论:帕罗西汀抗抑郁疗效肯定,副作用少。Objective：To study the efficacy and side effects of paroxetine in the treatment of depression. Methods：Sixty patients who met with the CCMD -3 criteria of depression were randomly divided into the research group （paroxetine） and control group （Imipramine） for the 6 -week treatment. The efficacy was assessed by Hamilton Depression Scale （HAMD） and Hamilton Anxiety Scale（HAMA）. The side effects were assessed by Treatment Emergent Symptoms Scale （TESS）. Results： Efficacy of paroxetine and imipramine was the similar （P 〉 0.05 ）. The improvement rate was 83.33% and 76.67% respectively. Paroxetine had effect on anxiety symptom with less side effects. Conclusions：Paroxetine is an effective and safe antidepressant.

关 键 词：帕罗西汀 丙眯嗪 抑郁症 

分 类 号：R971.43[医药卫生—药品] R749.41[医药卫生—药学]