眼镜蛇毒对大鼠脊髓乙酰胆碱酯酶表达的影响  

Effect of Naja naja atra Venom on Expression of Acetylcholine Esterase in Spinal Cord of Rats

作　　者：赵祥[1] 李怀斌[1] 熊克仁[1] 

机构地区：[1]皖南医学院解剖学教研室,安徽芜湖241001

出　　处：《蛇志》2005年第4期233-236,共4页Journal of Snake

基　　金：皖南医学院中青年科研基金资助课题(编号:WK200505B)。

摘　　要：目的 探讨眼镜蛇毒对大鼠腰髓乙酰胆碱酯酶(AchE)表达的影响。 方法将蛇毒注射到大 鼠左小腿下部,采用亚铁氰化铜法示AchE,观察大鼠腰髓前角Ache阳性神经元在眼镜蛇毒中毒组、生理 盐水组、正常对照组的变化． 结果蛇毒组大鼠AchE阳性神经元比对照组表达增强。 结论 眼镜蛇 毒对腰髓的AchE阳性神经元表达有上调作用。Objective To investigate the effect of Naja naja atravenom on the expression of acetylcholine esterase （AchE） in spinal cord of rat . Methods The methods of acetylcholinesterase histochemical technique were used to observe the expressions of Ache positive neurons in anterior horn at different groups. Results Naja naja atravenom could increase the number of Ache positive neurons in anterior horn of lumbar section of spinal cord （P〈0. 01）, the number of Ache positive neurons began to increase at 1h, got peak at 6h, and began to decrease at 24h, it recovered to normal at 48h. Conclusions Naja naja atravenom could increase the expressions of Ache positive neurons in spinal cord of rat.

关 键 词：眼镜蛇毒 脊髓 乙酰胆碱酯酶 大鼠 

分 类 号：R996.3[医药卫生—毒理学]