4-(对羟基苄基)-噁唑-2-硫酮的合成研究  

Synthesis and investigation of 4-(p-hydroxyl)-benzyl oxazolidine-2-thione

作　　者：陈家念[1] 杨桂春[1] 陈祖兴[1] 

机构地区：[1]湖北大学化学与材料科学学院,湖北武汉430062

出　　处：《湖北大学学报（自然科学版）》2005年第4期369-372,共4页Journal of Hubei University：Natural Science

基　　金：国家自然科学基金(No:20372019)资助项目

摘　　要：酪氨酸的氨基和酚羟基经Boc和苄基保护后,氢化铝锂还原及脱保护得酪氨醇.酪氨醇在Et3N作用下与CS2反应关环得一种新的Evans试剂—4-(对羟基苄基)-噁唑-2-硫酮,总产率达46%,探讨了投料比、时间和温度对反应的影响.Described a new kind of Evans reagent-4 - （ p -hydroxyl） -benzyl oxazolidinethione which was prepared ：by following six steps： amino protection, esterification and hydroxyl protection, reduction by Li- A1H4, deprotection, cyclization with triethylamine. Total yields were 46 % and tile factors influencing each step＇s productivity, such as the ratio of materials, time of the reaction and temperature of the reaction were investigated.

关 键 词：酪氨酸 还原 合成 嗯唑-2-硫酮 

分 类 号：O623.734[理学—有机化学]