降压药对高血压患者氧化应激影响的观察  

Effect of different antihypertion drugs on oxidative stress

作　　者：陈珍严[1] 刘靖[1] 李呐[1] 

机构地区：[1]深圳市第二人民医院,广东深圳518004

出　　处：《中国冶金工业医学杂志》2005年第6期608-609,共2页Chinese Medical Journal of Metallurgical industry

摘　　要：目的:观察不同类别降压药物对高血压患者氧化应激水平的影响。方法:通过比较使用不同降压药(分别为ACEI、ATⅡ、β受体阻滞剂及钙通道拮抗剂)3月后患者的IL6、CRP和血清微量元素水平的变化,评估机体的氧化应激水平。结果:使用ACEI类和ATⅡ类降压药的患者,3月后血清铜水平下降,锌水平上升,CRP和IL6水平下降。结论:ACEI和ATⅡ类降压药有调低氧化应激水平的作用,而在其他降压药物中未发现此种改变。Objective： To observe the effect on oxidative stress level in patients with essential hypertension after taking antihypertension drugs. Methods： Serum level of IL-6,CRP and trace elements were tested after the therapy of three months, Results： IL-6, CRP and copper level in patients taking ACEI and AT-Ⅱ for three months were decreased,zinc level ncreased Conclusions： ACEI and AT-Ⅱ have effects on oxidative stress.

关 键 词：降压药 高血压 氧化应激 

分 类 号：R544.1[医药卫生—心血管疾病]