反流性食管炎治疗的生存质量和成本-效果分析  

Quality of Life and cost-effectiveness of Different Therapy for Reflux Esophagitis

作　　者：刘芙成[1] 潘涛[1] 茅为涛[1] 

机构地区：[1]成都市第一人民医院消化内科,成都610016

出　　处：《药物流行病学杂志》2005年第6期357-359,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:评价埃索美拉唑治疗反流性食管炎(RE)的不同方案对患者生存质量的改善,并作成本一效果分析。方法:RE患者61例随机分成2组。A组:埃索美拉唑40 mg qd 8周;B组:先予埃索美拉唑40 mg qd,2周再予埃索美拉唑20 mg qd 6周。2组同时联用莫沙比利5 mg tid,8周。结果:A组与B组的症状有效率和内镜有效率差别均无统计学意义(P>0．05)。SF-36量表评分2组都有5个维度积分较治疗前提高。B组的成本一效果比更佳。结论:对于RE患者,先予埃索美拉唑40 mg每日1次2周,再予埃索美拉唑20 mg每日1次6周与莫沙比利联合可能为更经济有效的选择。Objective： To evaluate quality of life（QOL） and cost-effectivness of different plan of esomeprazole for reflux esophagitis （RE）. Method： 61 RE patients were randomized to 2 groups. Group A： esomeprazole 40mg once daily for 8 weeks; Group B： esomeprazole 40mg once daily for 2 weeks and then esomeprazole 20mg once daily for 6 weeks. All patients took mosapride 5mg three times daily for 8 weeks. Result： There was no statistic difference between group A and B in symptomatic effective rate and endoscopic effective rate. The scores of BP, GH, VT, SF and MH scales had significant improvement in group A and B after treatment. Group B was more cost effective. Conclusion： Esomeprazole 40mg once daily for 2 weeks and then esomeprazole 20mg once daily for 6 weeks pals mosapride perhaps the more cost effective therapy for RE patients.

关 键 词：反流性食管炎 生存质量 成本-效果分析 

分 类 号：F407.7[经济管理—产业经济]