辛伐他汀对阿霉素肾病大鼠肾皮质细胞凋亡的影响  

Effect of simvastatin on the apoptosis in the renal cortex of rats with adriamycin nephropathy

作　　者：尤燕舞[1] 王洁[1] 林栩[1] 杨发奋[1] 

机构地区：[1]右江民族医学院附属医院肾内科,广西百色533000

出　　处：《右江医学》2005年第6期573-574,F0003,共3页Chinese Youjiang Medical Journal

基　　金：右江民族医学院科研项目资助[(2004)42号]

摘　　要：目的研究辛伐他汀对阿霉素肾病大鼠肾皮质细胞凋亡的影响。方法将36只大鼠随机分为三个实验组,对照组(n=12)正常饲养,肾病组(n=12)注射阿霉素建立肾病模型,治疗组(n=12)在肾病组基础上给予辛伐他汀干预,每组各取6只大鼠分别饲养4周和8周,最后用TUNEL法分析细胞凋亡。结果与对照组比较,肾病组肾皮质中细胞凋亡显著增加(P<0.01),而辛伐他汀治疗组肾皮质中细胞凋亡较肾病组减少(P<0.01)。结论辛伐他汀可通过减少阿霉素肾病大鼠肾皮质细胞凋亡而实现肾保护作用。Objective To investigate the effect of simvastatin on the apoptosis in the renal cortex of rats with adriamycin nephropathy（ADN）. Methods Animals were randomly divided to three groups：normal control group, ad- riamycin-induced nephropathy group and treatment group which got AND and was treated with simvastatin（10 mg· kg^-1· d^-1 ）. Apoptosis was detected by TUNEL method. Results The apoptosis in the renal cortex of rats in adriamycin--induced nephropathy group was significantly increased, while decreased in treatment group. Conclusion Simvastatin may prevents renal from damage of adriamycin by reducing apoptosis.

关 键 词：阿霉素肾病 细胞凋亡 辛伐他汀 

分 类 号：R96[医药卫生—药理学]