乙型肝炎基因重组疫苗免疫效果及持久性观察  

Study on Immune Effect and Persistence of Recombinant Yeast-derived Hepatitis B Vaccine

作　　者：邓韶英 柯建厚 孙亚军[1] 徐郁[1] 肖慧洁 梁卫华[1] 黄小平[1] 朱江霞[1] 

机构地区：[1]珠海市疾病预防控制中心,广东珠海519000

出　　处：《实用预防医学》2005年第6期1321-1322,共2页Practical Preventive Medicine

摘　　要：目的探讨乙肝基因重组疫苗对新生儿的免疫效果及免疫持久性.方法随机选择珠海市1999～2003年出生、母亲HBsAg阴性、严格按免疫程序及时全程完成3针基础国产基因重组乙肝疫苗(5ug)的儿童,按免疫后不同的时间段分成6组,采集静脉血分别进行抗-HBs、HBsAg和抗-HBc检测.结果抗-HBs有效阳性率(≥10 mIU/ml)、几何平均滴度(GMT)逐年下降,分别由基础免疫完成后1个月的95.45%和65.36 mIU/ml,降至4年后的38.27%和6.56mIU/ml,免疫1年后的下降率最为显著.及时完成3针基础乙肝疫苗免疫后各不同时间段的儿童HBsAg阳性率均不超过1%,抗-HBc阳性率和HBV感染率均小于2%,未见随年限延长而增张的趋势.结论基因重组乙肝疫苗在新生儿中免疫效果良好,存在较好的免疫持久性和保护效果,在全程免疫后5年内没有必要进行加强.Objective To understand the immunization efficacy and durability of the DNA recombinant yeast-derived hepatitis B vaccine. Methods One thaousand and ninety newborns from 1999 through 2003 were randomly selected in Zhuhai. They had immunized with full course of the DNA recombinant yeast- derived hepatitis B vaccine; based on the duration after immunization divided into six groups. Their serum HBsAg, anti - HBc and anti - HBs were detected by ELISA. Results The positive rate of anti- HBs was 9.5.45 %, the geometric mean titres（GMT） were 29.21mlU/ml initially after their basic vaccination, which were declined 4 years later to 38.27 % and 6.56mlU/ml, and showed a progressive decline trend that were most evident during the first post-vaccination year. The positive rates of HBsAg remained less than 1%, anti - HBc positive rate and infection rate of HBV remained less than 2% after vaccination, however. Conclusion The protective efficacy of recombinant yeast- derived hepatitis B vaccine in newborn is satisfactory, which have long-term immunization memory and need not to receive booster immunization within .5 years after basic vaccination.

关 键 词：重组(酵母)乙肝疫苗 免疫效果 持久性 观察 

分 类 号：R512.62[医药卫生—内科学]