分子蒸馏技术提纯帕罗西汀碱  

Purification of paroxetine base by molecular distillation technology

作　　者：应安国[1] 许松林[1] 王淑华[1] 

机构地区：[1]天津大学精馏技术国家工程研究中心,天津300072

出　　处：《化学工程》2005年第6期59-62,共4页Chemical Engineering(China)

基　　金：国家自然科学基金资助项目(20176037)

摘　　要：应用刮膜式分子蒸馏装置对帕罗西汀的提纯进行了研究。考察了多种分离工艺参数对帕罗西汀质量分数、纯度和馏出率的影响。得到了分子蒸馏技术提纯帕罗西汀的最适宜工艺条件:进料速度60 mL/h,进料温度80℃,蒸发温度163℃,蒸发压力0.1 Pa。通过对该生产过程技术经济的初步分析,以年产1000 kg帕罗西汀计算,可产生利润约7000万元。The technology of refining paroxetine base by molecular distillation was studied. This process has high separation capacity and is more efficient than other traditional separation methods. The effects of operating parameters on product purification and distillation rate were obtained, the optimum operation parameters include： feed flow rate 60 mL/h, feed temperature 80 ℃ , distillation temperature 163 ℃ , operation pressure 0.1 Pa and rotor rate 130 r/min. The economical analysis of the whole process showed that there is a huge profit for the purification of paroxetine base by molecular distillation.

关 键 词：分子蒸馏 短程蒸馏 帕罗西汀 帕罗西汀碱 

分 类 号：TQ464.4[化学工程—制药化工]