桑叶提取液对实验性大鼠静脉血栓形成的影响  

The Effects of Mori Folium Extract Solution on Experimental Venous Thrombosis among Rats

作　　者：徐爱良[1] 彭延古[1] 熊湘平[1] 雷田香[1] 曾序求[1] 付东云[1] 陈艳芳[1] 

机构地区：[1]湖南中医学院,湖南长沙410007

出　　处：《中国中医药信息杂志》2005年第12期24-25,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：湖南省自然科学基金资助(03jj4015)

摘　　要：目的探讨桑叶提取液对实验性大鼠静脉血栓形成的影响。方法采用结扎大鼠腹腔主静脉造成的静脉血栓模型,观察其对纤溶、凝血等指标的影响。结果桑叶提取液能明显减轻大鼠静脉血栓重量,显著延长大鼠血浆的凝血活酶时间(APTT)、凝血酶原时间(PT)和凝血酶时间(TT),抑制纤溶酶原激活物抑制剂(PAI)的活性,同时使组织型纤溶酶原激活物(tPA)和抗凝血酶(AT-Ⅲ)的活性增强。结论桑叶提取液具有明显的抑制血栓形成作用,其抗血栓作用主要是通过抗凝血作用和纤溶系统而实现的。Objective To investigate the effects of Mori folium extract solution on experimental venous thrombus among rats. Methods The effects of Mori folium extract solution on antithrombosis was investigated on the changes of plasmins and cruor in the venous thrombus models established by ligating the celiac vein among rats. Results The mori folium extract solution could significantly alleviate the weight of venous thrombus, elongate the exsisting time of APTT, PT and TT of plasma, inhibit the PAI activity and increase the tPA activity and AT-Ⅲ activity at the same time. Conclusions The mori folium extract solution holds obvious effects of antithrombosis, which may be mainly related to its functions of anticoagulation and its influence on plasminogen system.

关 键 词：桑叶提取液 抗凝作用 血栓形成 大鼠 

分 类 号：R285.5[医药卫生—中药学]