不同类型冠心病病人血浆血栓前体蛋白和纤维蛋白原含量的变化  

The Thrombus Precursor Protein and Fibrinogen in Patients with Coronary Heart Disease

作　　者：蔡凯[1] 徐辉[1] 夏明凯[1] 黄超龙[1] 李介华[1] 张小勇[1] 邱敏[1] 廖永华[1] 

机构地区：[1]暨南大学医学院第五附属医院/广东省清远市人民医院

出　　处：《中西医结合心脑血管病杂志》2005年第12期1035-1036,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨血栓前体蛋白(TPP)、纤维蛋白原(Fg)水平,以评估不同类型冠心病病人高凝、血栓形成的临床意义。方法采用定量酶联免疫吸附法和全自动血凝分析仪检测冠心病病人112例,其中急性心肌梗死(AMI)46例,不稳定型心绞痛(UA)31例,稳定型心绞痛(SA)35例,另设20名正常体检者为对照组。结果TPP和Fg的阳性发生率及含量,UA组和AMI组明显高于SA组及对照组(P<0.01);SA组病人的Fg与对照组比较无统计学意义(P>0.05);SA组病人的TPP与对照组比较有统计学意义(P<0.05);Fg与TPP呈正相关(r=0.61,P<0.05)。结论冠心病病人TPP及Fg含量越高,越易发生AMI;UA组TPP、Fg增高者可有血栓形成。TPP和Fg可作为预测冠心病病人发生新鲜血栓形成的指标。Objective To study the relationship between thrombus precursor protein （TPP） and fibrinogen（Fg） and coronary heart disease （CHD）. Methods The levels of plasma TPP and Fg were detected by ELISA and auto blood coagulation instrument in 46 patients （pts） with acute myocardial infarction （AMI）, 31 pts with unstable angina pectoris（UA）, 35 pts with stable angina pectoris （SA）, and 20 controls, respectively. Results The positive rate and levels of TPP and Fg were significantly higher in UA and AMI groups than that in SA and control groups（P 〈0.01 ）. There was no significant difference in Fg levels in SA group compared with that in control group（P〉0.05）. There was significant difference in TPP levels in SA group compared with that in control group（P〈 0.05）. There were positive correlation between the levels of TPP and the levels of Fg in pts with CHD （ r = 0.61, P 〈 0.05）. Conclusion Pts with high levels of TPP and Fg had a trend of AMI. High TPP and Fg were associated with thrombosis in UA group, TPP and Fg could be the index for fresh thrombosis in pts with CHD.

关 键 词：关键词:血栓前体蛋白 血栓 纤维蛋白原 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病] R256.2[医药卫生—内科学]