羟基磷灰石涂层的电化学可控制备及生物性能的初步表征  

Electrochemical Controllable Preparation of Hydroxyapatite Coating with Different Morphologies and Preliminary in Vitro Tests

作　　者：时海燕[1] 胡仁[1] 林昌健[1] 

机构地区：[1]固体表面物理化学国家重点实验室厦门大学化学系,福建厦门361005

出　　处：《电化学》2005年第4期440-445,共6页Journal of Electrochemistry

基　　金：国家自然科学基金(20273055);教育部博士点基金(20020384012);国家863研究计划(2003AA302230)资助

摘　　要：控制不同沉积条件制备不同结构形貌的羟基磷灰石涂层,主要获得3种由不同尺寸晶粒构成的直立状、花簇状和多孔状典型形貌特征的涂层;XRD物相分析显示,该涂层主要由结晶良好的羟基磷灰石组成;FT-IR组分分析未检测到其他钙磷盐成分的存在.体外细胞培养试验表明,以上各种形貌的羟基磷灰石涂层均具有良好的生物相容性,但其生物活性则因形貌而异,其中纳米有序多孔状羟基磷灰石涂层表现出最高的生物活性,而花簇状的涂层生物活性相对较低.The Controllable electrochemical deposition has been developed to prepare the hydroxyapatite （HA） coatings on Ti substrate with different morphologies and structures. Three kinds of typical topography of HA coatings, i.e. standing - up, flower and ordered porous structures have been obtained. The XRD and FTIR results demonstrate high crystallinity of the coating and exclusion of other forms of calcium phosphates. In vitro tests reveal that the biological property is largely dependent on the structure and morphology of the HA coating. It has been found that all pure HA coating show good biocompatibilities, while only the HA coating with ordered porous structures exhibits best bioactivities.

关 键 词：羟基磷灰石涂层 结构有序 电化学沉积 生物性能 

分 类 号：O627.51[理学—有机化学]