国产皮下埋植剂因月经异常停用的影响因素分析  

Risk Factors for Discontinuation of Norplant Implants Due to Menstrual Irregularities

作　　者：曾庆枝[1] 周维谨[2] 车焱[2] 韩耀玲[2] 高尔生[2] 方可娟[2] 范彗民 关艳敏 

机构地区：[1]复旦大学公共卫生学院,上海市计划生育科学研究所200032 [2]上海市计划生育科学研究所 [3]北京妇产医院 [4]辽宁省计划生育科学研究院

出　　处：《中国计划生育学杂志》2005年第12期739-742,共4页Chinese Journal of Family Planning

摘　　要：Objective: To analyze the risk factors for the discontinuation of two types of Norplant implants due to menstrual irregularities during 5-year use among Chinese parous women. Methods: A multi-centre randomized controlled clinical trial was undertaken in eight institutes of China. The data from 14,805 women (7,395 cases of Norplant-I, 7,410 cases of Norplant-II) were analyzed by the methods of life-table and COX Stepwise regression procedure. Results: Menstrual irregularities was the primary factor for discontinuation of implants. The cumulative discontinuation rate after five-year using was 17.00 per 100 women in Norplant-I and 15.26 per 100 women in Norplant-II, respectively. Discontinuation risk due to bleeding seemed to be influenced by educational level, occupation, parity, prior contraceptive use, breastfeeding status, body weight and regions where users lived in. Discontinuation risk for amenorrhea was probably influenced by the type of implant, occupation, parity, breastfeeding status and regions where users lived. Conclusion: Comprehensive counseling and effective treatment are key to reduce the impact of menstrual irregularities and improve the acceptability of the implants.Objective： To analyze the risk factors for the discontinuation of two types of Norplant implants due to menstrual irregularities during 5 - year use among Chinese parous women. Methods ： A multi - centre randomized controlled clinical trial was undertaken in eight institutes of China. The data from 14,805 women （7,395 cases of Norplant - Ⅰ, 7,410 cases of Norplant - Ⅱ） were analyzed by the methods of life - table and COX Stepwise regression procedure. Results： Menstrual irregularities was the primary factor for discontinuation of implants. The cumulative discontinuation rate after five - year using was 17.00 per 100 women in Norplant - Ⅰ and 15.26 per 100 women in Norplant - Ⅱ, respectively. Discontinuation risk due to bleeding seemed to be influenced by educational level, occupation, parity, prior contraceptive use, breastfeeding status, body weight and regions where users lived in. Discontinuation risk for amenorrhea was probably influ- enced by the type of implant, occupation, parity, breasffeeding status and reg/ons where users lived. Conclusion： Comprehensive counseling and effective treatment are key to reduce the impact of menstrual irregularities and improve the acceptability of the implants.

关 键 词：国产皮下埋植剂 月经异常 停用 影响因素 

分 类 号：R169.41[医药卫生—公共卫生与预防医学] R711.51