n-3PUFA调节脂代谢机制的研究进展  

Effect of n-3PUFA on the Expression of Genes Involved in Lipid Metabolism

作　　者：屈长青[1] 张国华[1] 赵丽丽[1] 杨公社[1] 

机构地区：[1]西北农林科技大学动物脂肪沉积与肌肉发育实验室,杨凌712100

出　　处：《中国生物工程杂志》2005年第B04期137-140,共4页China Biotechnology

基　　金：国家自然科学基金资助项目(30471239)

摘　　要：日粮中的n-3PUFA具有多种作用,除了调节质膜组成和影响细胞信号之外,同时还涉及多 种与脂代谢有关酶与蛋白的基因表达,如:PPARα、SREBPs、LXR等,通过它们来影响靶基因(如: ACO-A、FAS等)的表达,从而起到调控脂肪沉积的作用。PUFA are important components of membranes and they take part in the process of energy metabolism and signal transduction of cells. They can also control adipocyte differentiation and have effect on the expression of genes encoding enzymes and proteins involved in lipid metabolism, as a result, they can regulate animal lipid metabolism and reduce body fat deposition. There are many transcription factor have been indentified as targets for PUFA regulation, including PPARa, SREBPs, LXR et al. additional, the metabolic material of PUFA can decrease expression of lipogenic genes.

关 键 词：多不饱和脂肪酸(PUFA) 脂肪代谢 表达 调控 

分 类 号：Q78[生物学—分子生物学] S968.4[农业科学—水产养殖]