实验冻伤大鼠神经纤维的超微结构改变  

Ultrastructural changes of nerve fiber in the rat with experimental frostbite

作　　者：杨惠彬[1] 王之贤[1] 李凤芝[1] 祝品金 颜培华[1] 张国春 于涛 

机构地区：[1]军事医学科学院卫生学环境医学研究所

出　　处：《中华劳动卫生职业病杂志》1996年第4期204-206,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：为探讨冷冻损伤发生、发展及转归的规律，采用健康Ｗｉｓｔａｒ大鼠，分为冻伤组（２０只）和对照组（５只）。电镜下观察大鼠后肢冷冻至－２０℃后即刻、４小时、２４小时及７２小时时周围神经的超微结构改变。冻后即刻，神经髓鞘即出现轻度变性；冻后１～２４小时，有髓神经雪旺细胞及轴突严重变性，而无髓神经变性较轻；冻后７２小时，神经溃变及修复并存，无髓神经较有髓神经易于修复。The ultrastructural changes in the peripheral nerve fiber of the rat hindlimb cooled to-20℃ were observed.Biopsies were taken at 0,4,24 and 72 h after freezing.Slight degeneration oc-curred in myelin sheath immediately after cold exposure.Serious degeneration was seen in Schwann'scell and axon of the myelinated nerve fiber4～24 h after cold exposure,and less severe in unmvelinatednerve fiber.Both degradation and repair existed at 72 h.The restored ultrastructure was better in mvelinated nerve fiber than that in unmvelinatad one.

关 键 词：冻伤 神经纤维 超微结构 

分 类 号：R645.02[医药卫生—外科学] R361.3[医药卫生—临床医学]