R6G和R6Gzn的体内抗肿瘤作用研究  

Antitumor EHect of R6G and R6Gzn in Vivo

作　　者：柴彪新[1] 李亢宗[1] 

机构地区：[1]兰州医学院生化教研室,北京军事医学科学院

出　　处：《兰州医学院学报》1996年第2期4-6,共3页Journal of Lanzhou Medical College

摘　　要：本文研究了Ｒ６Ｇ和Ｒ６Ｇｚｎ对小鼠Ｓ１８０和Ｕ１４实体瘤的生长抑制作用。证明，Ｒ６Ｇ和Ｒ６Ｇｚｎ的剂量在４ｍｇ／ｋｇ时，对Ｓ１８０的抑制率分别为３５．２％和３５．２％，对Ｕ１４瘤的抑制率分别为３６％和３２．４％，两者无明显差异。Ｒ６Ｇ和Ｒ６Ｇｚｎ对小鼠的１．Ｄ５０分别为２５．１４±２．４７ｍｇ／ｋｇ和２８．７４±９．９７ｍｇ／ｋｇ；对荷瘤小鼠的脾脏指数和胸腺指数均有降低的趋势。本文还对罗丹明类的抗癌机理进行了讨论。n present paper the antitumor activity of R6G and R6GZn on transplanted mice solid tumor S180 andU14 were studied in vivo. The inhibition rate(IR%)of R6G and R6GZn on S180 were 35.5%and 35.5%,on U14 cancer were 36.0%and 32.4%respectively.LD50 of R6G and R6GZn on mice were 25.14± 2.47mg/kg and 28.74±9.97mg/kg respectively. Both R6G and R6GZn had tendency to reduce spleen index and thy-rnus index. The rnechanism of antituor effect was also discussed.

关 键 词：罗丹明6G 罗丹明6G锌 S180瘤 抗肿瘤作用 

分 类 号：R979.1[医药卫生—药品] R73－361[医药卫生—药学]