肝移植对大鼠胃排空和胃电的影响及意义  

Effect of gastric emptying and electricity of gastric graph on liver transplantation before and after and its significance in rats

作　　者：王胜智[1] 王景杰[2] 黄裕新[2] 王旭霞[2] 马庆久[1] 何显力[1] 秦云霞[1] 

机构地区：[1]第四军医大学唐都医院普通外科,陕西西安710038 [2]第四军医大学唐都医院消化内科,陕西西安710038

出　　处：《中国现代医学杂志》2005年第22期3417-3419,3423,共4页China Journal of Modern Medicine

摘　　要：目的探讨肝移植前后,肝硬化大鼠胃排空和胃电变化情况,为临床施以肝移植术后观察胃动力恢复提供理论依据。方法制备CCl4中毒性肝硬化大鼠模型,采用“二袖套法”进行肝移植,利用浆膜法检测胃电;应用放免分析法,使用放射性核素锝(99Tcm),采取液相胃排空的方法,分析肝移植前后大鼠胃排空的情况。结果肝移植前,胃排空产生明显障碍,胃电活动呈现紊乱状态。肝移植后,随着时间的不断延长,大鼠胃排空状况明显改善(P<0.01),胃电活动趋于规律。结论肝硬化可导致胃排空障碍以及胃电活动紊乱。肝移植可明显改善因肝硬化所致的胃排空障碍,使紊乱的胃电活动趋于规律。[Objective] To detective the changes of rats gastric emptying and electricity of gastry before and after liver transplantation. [Methods] Hepatic cirrhosis model was established in rats by subcutaneous injections of 40% Carbon tetraehloride. Rat liver transplantation was made with two-cuff technique. Gastric emptying was analyzed with radioimmunoassay, using nuclide 99Tem and gastric emptying of liquids and EGG with the serosa method before and after liver transplantation. [Results] The time of gastric emptying prolonged and the structure of gastric mueosa was damaged before transplantation. After transplantation, we found the EGG approached to regular and gastric emptying was improved significantly （P 〈0.01 ） and the tissue structure of gastric mueosa resumed after transplantation. [Conclusions] Transplantation can improve the destruction of gastric function

关 键 词：肝硬化 肝移植 大鼠 胃排空 胃电 

分 类 号：R725[医药卫生—儿科]