脐血乙肝指标与预防接种失败的关系  

Relation of HBV marks in umbilicus cord blood with failure of preventing inoculation

作　　者：马士恒[1] 王占国[1] 王红英[2] 苏新桃 李艳红[2] 宫克[1] 李建恒[1] 

机构地区：[1]河北省职工医学院传染病学教研室,河北保定071000 [2]湖北省保定市妇幼保健院,河北保定071000

出　　处：《中国现代医学杂志》2005年第22期3450-3452,共3页China Journal of Modern Medicine

摘　　要：目的探讨新生儿脐血血清学、病毒学指标与乙肝预防接种失败的关系。方法应用ELISA法检测HBV慢性感染产妇所产新生儿脐血的HBV血清学标志物,应用FQPCR法检测HBVDNA。结果“大三阳”产妇婴儿脐血中HBVDNA阳性率较“小三阳”产妇高(χ2=5.52,P<0.025)。脐血HBsAg(+)、抗-HBcIgM(+)、HBeAg(+)、HBVDNA(+)是影响新生儿常规预防接种失败的危险因素(OR值分别为10、45、15.56、51.6和95%CI分别为2.64～37.93、7.69～263.21、4.45～54.40和14.72～180.83)。结论对脐血中HBsAg阳性、抗-HBcIgM阳性、HBeAg(+)或HBVDNA阳性的新生儿应进一步采取更积极有效的干预措施。对HBV慢性感染产妇脐血进行HBVm及HBVDNA筛查有实际意义。[Objective] To study the relation of umbilicus cord blood HBV marks in neonates with failure of preventing inoculation. [Methods] ELISA was employed to detect the HBV marks in umbilicus cord blood of HBsAg positive pregnant women, fluorescence PCR to detect the HBV DNA. [Results] The positive rate of HBV DNA in HBsAg, anti-HBc and HBeAg positive pregnant women were higher than in HBsAg, anti-HBc and anti-HBe positive pregnant women （X^2=5.52,P 〈0.025）. HBsAg（＋）, anti-HBc IgM（＋）, HBeAg（＋）and HBV DNA（＋）in umbili- cus cord blood Were risk factors effecting neonate routine preventing inoculation （OR： 10, 45, 15.56, 51.6 respectively, 95% CI： 2.64～37.93, 7.69～263.21, 4.45～54.40, 14.72～180.83 respectively）. [Conclusion] In neonates with HBsAg（＋）, anti-HBc IgM（＋）, HBeAg（＋） or HBV DNA（＋） of umbilicus cord blood, more effective immunity measure should be applied. Detecting the HBV marks and HBV DNA of umbilicus cord blood in neonate born to HBsAg positive pregnant woman had realistic signification.

关 键 词：脐血 HBV血清学标志物 HBV DNA 母婴传播 

分 类 号：R512.62[医药卫生—内科学]