急性心肌梗死患者血浆蛋白C和D-二聚体测定及临床意义  

Determination of protein C and D-dimer in patients with acute myocardial infarction and its clinical significance

作　　者：蹇在伏[1] 解勤之[1] 陈方平[1] 

机构地区：[1]中南大学湘雅医院血液科,湖南长沙410008

出　　处：《中国现代医学杂志》2005年第22期3472-3473,共2页China Journal of Modern Medicine

摘　　要：目的探讨急性心肌梗死患者血浆蛋白C活性和D-二聚体水平及意义。方法采用发色底物法(蛋白C)和免疫比浊法(D-二聚体)对22例急性心肌梗死患者血浆蛋白C活性和D-二聚体进行了检测,并与正常对照组(n=20)进行比较。结果急性心肌梗死患者血浆D-二聚体水平明显高于正常对照组(P<0.01),而蛋白C活性检测与正常对照组没有明显差别(P>0.05)。结论蛋白C不是引起急性心肌梗死的主要因素,D-二聚体增高对于诊断急性心肌梗死具有一定的价值。[Objective] To study the clinical significance of plasma levels of protein C and D-dimer in patients with acute myocardial infarction （AMI）. [Methods] Synthetic chromogenic substrate method （protein C） and immune-chromatogram method （D-direct） were used to detect the plasma levels of protein C and D-dimer in 22 cases of AMI,and compared with the normal control group （n=20）. [Results] The plasma levels of D-dimer in patients with AMI was obviously higher than normal control group （P 〈0.01）. There was no significant difference of protein C activity between AMI and normal control groups （P 〉0,05）. [Conclusion] Protein C was not main risk factor for AMI, increased level of D-dimer was significant for diagnosing AMI.

关 键 词：心肌梗死 蛋白C D-二聚体 

分 类 号：R542.22[医药卫生—心血管疾病]