聚乙二醇单甲醚一聚(D,L-乳酸)嵌段共聚物的研究  

Studies on Methoxy Poly(ethylene glycol)-Poly(D,L-lactic acid)block copolymers

作　　者：邓联东[1] 姚芳莲[1] 孙多先[1] 姚春梅[1] 董岸杰[1] 

机构地区：[1]天津大学化工学院,天津300072

出　　处：《中国生物医学工程学报》2005年第6期736-739,共4页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金资助课题(30170227)

摘　　要：采用熔融缩聚反应合成一系列聚(D,L-乳酸)(PDLLA)/聚乙二醇单甲醚(mPEG)两亲性二嵌段共聚物(PEDLLA),采用IR、1H-NMR、DSC、WAXD和TEM等手段分析和研究PEDLLA的结构与性能。实验结果表明,PEDLLA的结构和组成与设计相一致,结晶度和熔点均低于均聚物,且随着PEDLLA中PDLLA含量的增加,mPEG嵌段熔点降低,随着PDLLA嵌段相对分子质量的增大,PEDLLA降解速率增大。载药纳米粒呈核壳结构,载药量达30%。Amphiphilic diblock copolymers （PEDLLA） were prepared from D, L-lactic acid （DLLA） and methoxy poly （ethylene glycol） （mPEG） by the melting polycondensation. The structure and the properties of copolymers were characterized by IR,^1H-NMR, DSC and WAXD respectively. The results showed that the structure and composition of PEDLLA were correspondent with the design, and the crystallinity and Tm were lower than that of the homopolymers, and Tm of mPEG segment decreased upon increasing the content of PDLLA in PEDLLA. The PEDLLA degradative rate increased upon increasing the PDLLA molecular weight. The drug-loaded nanoparticles showed sphere with inner core and outer shell and the drug-loaded amount was more than 25 % .

关 键 词：聚(D L-乳酸) 聚乙二醇单甲醚 聚乙二醇单甲醚-b-聚(D L-乳酸) 两亲性共聚物 嵌段共聚物 

分 类 号：R318[医药卫生—生物医学工程]