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作 者:薛伟明[1] 刘袖洞[2] 于炜婷[2] 马小军[2]
机构地区:[1]西北大学化工学院,陕西西安710069 [2]中国科学院大连化学物理研究所生物技术部,辽宁大连116023
出 处:《西北大学学报(自然科学版)》2005年第6期741-745,共5页Journal of Northwest University(Natural Science Edition)
基 金:国家自然科学基金资助项目(50373046;20176056);中国科学院知识创新工程领域前沿基金资助项目(K2002A2)
摘 要:目的制备蛋白质药物非注射给药载体。方法以生物相容性优良的海藻酸盐为载体材料,以血红蛋白为药物模型,通过设计凝胶浴配方,采用静电液滴形成工艺制备包封蛋白质药物的微球载体。结果微球球形度优良,粒径分布窄,蛋白质包封率达到95%。结论采用静电液滴工艺实现了蛋白质在海藻酸盐微球中的高效包封,为在微球表面形成均匀控释膜、制备粒径≤10μm蛋白质药物的口服给药微球载体奠定了基础。Aim To prepare the carries for non-injection administration of protein drugs. Methods Using biocompatible alginate as microsphere material and hemoglobin as drug model, protein-loaded microspheres were prepared by an improved technology based on electrostatic droplet generation via designing components of gelation solution. Results Protein-loaded microspheres showed good sphericity and narrow diameter distribution, the encapsulation efficiency reached 95%. Conclusion Hemoglobin was effectively encapsuled into alginate microspheres by improved electrostatic droplets generation, which would be a foundation not only for forming uniform controlled release membrane around the microsphere surface but also for preparing protein -loaded microspheres with size≤10μm for oral administration.
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