超临界CO_2反复循环萃取法制备PLA/TCP多孔组织工程支架材料  

PLA/TCP porous scaffolds for tissue engineering fabricated by repeatedly cycling extraction with supercritical CO_2

作　　者：邢禹彬[1] 李立华[1] 周长忍[1] 

机构地区：[1]暨南大学理工学院材料系生物材料研究室,广东广州510632

出　　处：《功能材料》2005年第12期1909-1912,共4页Journal of Functional Materials

基　　金：国家重点基础研究发展计划(973计划)资助项目(G1999054306);国家高技术研究发展计划(863计划)资助项目(2001A625050);吴健雄实验室开发基金资助项目(2004)

摘　　要：相对于传统的超临界CO2(SC-CO2)一次性升压法,采用SC-CO2反复循环萃取法制备了聚乳酸(PLA)/磷酸三钙(TCP)复合多孔支架材料,以提高材料的孔洞连通率.本文研究了材料的开孔率,不同PLA和TCP配比材料的孔洞形态以及材料的力学性能.结果表明,反复循环萃取法制备的材料比传统的一次性升压法制备的材料的开孔率可以提高10%左右,孔径在200～300μm之间,孔壁上有丝网型等几种适合细胞种植的特殊微隙形态;TCP在PLA支架中的分散性很好;材料压缩模量和压缩强度分别可达71.8和7.1MPa,比单纯的PLA材料明显增加.In this research,a new method of repeatedly cycling extraction comparing with traditional introduction one time was adopted to prepare poly lactic acid （PLA）/ tri-calcium phosphate （TCP） composite scaffold in which the pores were expected to be more interconnected. The open porosity,the shapes of different proportion of PLA/TCP and the mechanical capability had been investigated. The results showed below：the scaffolds made by this new method have 10% higher open porosity than those made by old one,and the diameter of the pores is between 200-300μm;there are several types of micro interspace in the pores and they are good for osteoblast’s growing; TCP is perfectly distributed in the scaffold; the compressure modulua and compressure strength are 71.8 and 7.1MPa respectively,which are obviously increased comparing with pure PLA scaffolds.

关 键 词：组织工程支架材料 超临界CO2 PLA/TCP 开孔率 

分 类 号：R318.08[医药卫生—生物医学工程]