感冒通性血尿患儿尿酶、血清LPO和SOD的变化  

Detection of Urinary Enzymes and Serum LPO and SOD in the Juvenile Patients with Hematuria Caused by Ganmaotong

作　　者：吴燕祥[1] 熊嗣玉[1] 杨杏鲜[1] 

机构地区：[1]武汉市儿童医院肾内科,430016

出　　处：《药物流行病学杂志》1996年第3期137-138,共2页Chinese Journal of Pharmacoepidemiology

摘　　要：观察了26例口服感冒通后引起血尿患儿血尿期及血尿后尿酶变化,发现多数病例血尿期尿N—Z酰—β—氨基葡萄糖苷酶(NAG)及α-葡萄糖苷酶(α-Glu)升高,血尿消失后多数病例恢复正常。根据尿酶检测结果结合病例临床特征分析:感冒通引起肾损害的主要部位可能在肾小管及肾间质。同时还观察了18例患儿血尿期及血尿后血清过氧化脂质(LPO)及超氧歧化酶(SOD)的变化,结果多数病例未见异常改变。Urinary enzymes in 26 juvenile patients with hematuria induced by Ganmaotong were detected in the course of the hematuria and after hematuria period. The results showed that there was an elevation of NAG and a-Glu activity in most of the cases in hematuria period, and they returned to normal levels after hematuria vanished. Our results suggested that the renal lesion caused by Ganmaotong may be located at uriniferous tubules and renal interstices. The LPO and SOD in 18 cases of juvenile patients in the hematuria period and late stage of hematuria were also examined, and no abnormal changed were found in most of the cases.

关 键 词：感冒通 血尿 尿酶 过氧化脂质 儿童 药源性疾病 

分 类 号：R595.3[医药卫生—内科学]