幽门螺杆菌感染与冠心病关系的配对病例对照研究  

Matching Case-control Study of the Relation Between Helicobacter Pylori and Coronary Heart Disease

作　　者：邓学良[1] 陈新[1] 李柏皖[2] 

机构地区：[1]南华大学公共卫生学院,湖南衡阳421001 [2]南华大学第三附属医院

出　　处：《南华大学学报（医学版）》2005年第4期499-500,504,共3页Journal of Nanhua University(Medical Edition)

摘　　要：目的探讨幽门螺杆菌(Helicobacter pylori,Hp)感染与冠心病及血浆纤维蛋白原的关系。方法以某单位冠状动脉造影确诊为冠心病(coronary heart disease,CHD)的现症病人为病例组,病例组共53例病人,按1∶1个体匹配的方法,选择与病例性别与吸烟情况相同、年龄在±5岁内,无高血压及心绞痛病史,此次体格检查心电图正常者为对照组,检测两组人群血液中HpIgG滴度及纤维蛋白原浓度并进行比较。结果CHD病例组血清HpIgG阳性率及血浆纤维蛋白原浓度均较对照组高(P<0.05),但冠心病病例组与对照组中HpIgG阳性者血清纤维蛋白原浓度与HpIgG阴性者差异无显著性。结论HP感染与冠心病的发生有关,慢性Hp感染不会导致血浆纤维蛋白原浓度升高。Objective To investigate the relation between Helicobacter pylori（Hp） infection and coronary heart（CHD）. Methods 53 patients with CHD and 53 controls matched for age ,gender and smoking randomly recruited from the register of health examination. HplgG in serum of the patients and controls was tested by ELISA. Their Fibrinogen（ Fg） in plasma was detected. Results 75.5 % of the CHD patients and 56.6% of the controls were seropositive for Hp. The OR was 3. The concentrations of plasma Fg in CHD group were higher than those in the control （ P 〈 0. 05 ）. The difference between the seropasitivity and seronegativity in CHD and controls was nonsignificant （ P 〉 0. 05 ）. Conclusion This study suggests that infection with Hp is associated with CHD and has no relation with plasma Fg.

关 键 词：冠心病 幽门螺杆菌 血浆纤维蛋白原 

分 类 号：R541.4[医药卫生—心血管疾病]