一株Stysanus like sp.属南海红树内生真菌代谢产物的研究  

Metabolites of a mangrove endophytic fungus stysanus like sp.from the south China sea

作　　者：朱峰[1] 林永成[2] 王军[3] 周世宁[3] Vrijmoed L LP 

机构地区：[1]佛山科学技术学院化学与化工系,广东佛山528000 [2]中山大学化学与化学工程学院,广东广州510275 [3]中山大学生命科学学院,广东广州510275 [4]香港城市大学生物学与化学系

出　　处：《化学研究与应用》2005年第6期790-792,共3页Chemical Research and Application

基　　金：国家863计划资助项目(2001AA624010);广东自然科学基金资助项目(04300674);广东省科技计划资助项目(2004B30101017)

摘　　要：Two metabolites(A and B) were isolated from a mangrove endophytic fungus Stysanus like sp.(#2492) from the South China Sea.Their structures were elucidated by spectral data as N-(2’-hydroxytetracosyl)-2-amino1,3,4-trihydroxyoctadecane(A) and γ-stearolactone(B).In the primary bioassay,compound B did not exhibit significant inhibitory activity to DNA topoisomerase hTOP Ⅰ,and also had no significant inhibitory activity to tumor cell lines Bel-7402 and NCIH-460.It was the first report that γ-stearolactone(B) isolated from marine fungus as natural product.Two metabolites（ A and B） were isolated from a mangrove endophytic fungus Stysanus like sp. （#2492） from the South China Sea. Their structures were elucidated by spectral data as N - （2＇ - hydroxytetracosyl） -2 - amino - 1,3,4 - trihydroxyoctadecane （A） and γ-stearolactone （B）. In the primary bioassay, compound B did not exhibit significant inhibitory activity to DNA topoisomerase hTOP Ⅰ , and also had no significant inhibitory activity to tumor cell lines Bel - 7402 and NCIH - 460. It was the first report that γ - stearolactone （B） isolated from marine fungus as natural product.

关 键 词：海洋真菌 代谢产物 N-(1’-羟甲基-2’ 3’-二羟基)十七烷基-2-羟基二十四碳酰胺 γ-硬脂酸内酯 生理活性 

分 类 号：O629.72[理学—有机化学]