睡眠剥夺与脑内的基因表达(英文)  

Sleep deprivation and gene expression in the brain

作　　者：叶晨静[1] 赵忠新[1] 

机构地区：[1]第二军医大学附属长征医院神经内科,上海200003

出　　处：《神经科学通报》2005年第6期432-435,共4页Neuroscience Bulletin

摘　　要：睡眠十分重要,并且有着非常精细的自稳调节,研究发现觉醒时间的延长总是伴随着睡眠时间和(或)强度补偿性地增加。睡眠的自稳调节现象表明一旦剥夺睡眠,脑的生理、生化或分子学过程便会发生显著变化,揭示这些变化可以为我们了解睡眠功能提供重要线索。Sleeping plays a more important role than just providing rest and is exquisitely involved in homeostatic regulation. Studies suggest that prolonged waking is always followed by a compensatory increase in the hours and/or the intensity of sleep. Such homeostatic regulation of sleep indicates that a distinct physiological, biochemical, or molecular process is altered once sleep is deprived. Revealing such processes may provide critical clues to determining the functions of sleeping. Studies show that sleep deprivation could change the expressions of certain genes in the brain, such as Hsp70, GRP78/Bip , BDNF/TrkB, glucose transporter 1, the fos/jun family, Chromogranin C, synaptotagmin Ⅳ, and prepro-orexin.

关 键 词：睡眠剥夺 觉醒 基因表达 

分 类 号：Q428[生物学—神经生物学]