International NeuroAIDS: prospects of HIV-1 associated neurological com-plications  

作　　者：J Roberto TRUJILLO Gilberto JARAMILLO-RANGEL Marta ORTEGA-MARTINEZ Augusto C PENALVA de OLIVEIRA Jose E VIDAL Joseph BRYANT Robert C GALLO 

机构地区：[1]Institute of Human Virology, University of Maryland Biotechnology Institute, 725 W Lombard Street, Baltimore, MD 21201, USA [2]Institute of Infectious Diseases Emilio Ribas,Sao Paulo 01246, Brazil ,Clinical Research Unit in Human Retrovirology, University of Campinas,Sao Paulo 01246, Brazil. [3]Institute of Infectious Diseases Emilio Ribas,Sao Paulo 01246, Brazil

出　　处：《Cell Research》2005年第11期962-969,共8页细胞研究（英文版）

摘　　要：Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain.

关 键 词：NeuroAIDS HIV- 1 neurotropism AIDS dementia complex 

分 类 号：R512.91[医药卫生—内科学]