丙泊酚在急诊气管插管镇静中的应用  

Application of Propofol in the Sedation for Tracheal Intubation of Emergency

作　　者：林小波[1] 陈浩波[1] 李晓莉[1] 伍雪英[1] 黎洁[1] 杨肖华[1] 

机构地区：[1]广东省肇庆市第一人民医院急诊科,广东肇庆526021

出　　处：《医学临床研究》2005年第12期1671-1673,共3页Journal of Clinical Research

摘　　要：[目的]观察丙泊酚在急诊清醒患者气管插管时的镇静效果.[方法] 40例需要机械通气且意识清醒的急慢性呼吸衰竭患者,随机分成试验组和对照组,每组20例.试验组:先静注丙泊酚1.5 mg/kg行静脉诱导,然后改用微量注射泵持续注射丙泊酚,达到理想镇静深度(Ramsay氏5级以上)后行气管插管;对照组:使用以往常用方法,地西泮10～20 mg静注,镇静后立即行气管插管.记录用药后达到镇静要求的时间、插管完成时间、插管损伤以及恶心、呕吐、屏气、呛咳等咽喉部反射的例数.[结果]试验组达到镇静要求时间、插管完成时间较对照组短(P<0.01);插管损伤以及咽喉部反射均较对照组少(P<0.05).[结论]丙泊酚用于急诊气管插管镇静能取得良好的效果,为抢救患者生命节省了时间.[Objective]To observe sedative effect of propofol used in mechanically ventilating patients in the emergency when they were sober-minded. [Methods]Forty patients were randomly divided into experiment group and control group. All patients had acute or chronic respiratory failure and needed to mechanical ventilation. In the experiment group： propofol 1.5mg/kg injected intravenously as sedative induction, followed by continuous intravenous infusion using injecting pump,tracheal intubation was done immediately after reaching ideal sedative profundity （above grade 5 of Ramsay gradation）. In the control group., valium 10-20mg was injected intravenously , followed by tracheal intubation. The time of reaching sedation, accomplishing tracheal intubation,injury of tracheal intubation and the number of patients with nausea, vomiting, breaths holding, choke, reflection of throat were recorded after using the drugs. [Results]The times of reaching sedation and accomplishing of tracheal intubation in experiment group were shorter than in control group（ P 〈0.01） ;injury of tracheal intubation and reflection of throat were fewer than in control group （ P 〈0.05）. [Conclusion]The use of propofol can get good sedative effect in tracheal intubation of emergency, and it can save more time to save patients lives.

关 键 词：插管法 气管内 急诊室 医院 

分 类 号：R472.9[医药卫生—护理学]