核酸对铅致大鼠氧化应激的影响  

Effect of Dietary Nucleic Acid on DNA oxidative damage of Peripheral Blood Lymphocyte Cells in Rats

作　　者：潘洪志[1] 陈文华[1] 邱向红[1] 欧阳吉芳[2] 李恕[2] 

机构地区：[1]哈尔滨医科大学公共卫生学院,哈尔滨150001 [2]珍奥集团股份有限公司,大连116620

出　　处：《微量元素与健康研究》2005年第6期7-8,共2页Studies of Trace Elements and Health

摘　　要：目的:研究核酸营养对大鼠外周血淋巴细胞DNA损伤的影响。方法:大鼠灌胃饮食核酸5周后,采用单细胞凝胶电泳技术对外周血淋巴细胞DNA损伤进行分析。结果:核酸组大鼠淋巴细胞DNA的迁移率和尾长均显著低于对照组(P<0.05)。结论:饮食核酸对淋巴细胞DNA损伤具有一定的保护作用。Objective：To observe the protective effect of Dietary Nucleic Acid on DNA damage. Method： The rats were given dietary nucleic acid . After 5 weeks, the DNA break in peripheral blood lymphocytes from the rats were analyzed with single cell gel electrophoresis. Results： Compared with control , the damage of DNA in Dietary Nucleic Acid group were reduced significantly（ P 〈 0. 05 ）, Conclusion： Dietary Nucleic Acid could protect DNA damage of peripheral blood lymphocytes in Rats.

关 键 词：饮食核酸 大鼠 DNA损伤 单细胞凝胶电泳 

分 类 号：O612.4[理学—无机化学] Q959.836[理学—化学]