TRFIA检测新生儿TSH作为非缺碘地区标志应用的研究  

The feasibility of TRFIA to test neonatal TSH as the symbol of iodine undeficiency area

作　　者：唐玉娣[1] 秦良谊[1] 王惠[1] 赵文彬[1] 

机构地区：[1]江苏省连云港市新生儿疾病筛查中心(江苏省连云港市第一人民医院),222002

出　　处：《中国妇幼保健》2005年第24期3282-3284,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨TRFIA检测新生儿TSH水平作为非缺碘地区标志应用的价值。方法:依据碘缺乏病监测资料,应用TRFIA技术检测新生儿72h足跟血(全血滤纸片)。结果:在人群环境碘营养状况基本符合IDD消除标准,TRFIA检测新生儿全血TSH>5mU/L的比率为2.57%(426/16548),而ELISA法为17.35%(1500/8644,2003年)。结论:TRFIA检测新生儿出生72h足跟血(滤纸片)TSH<5mU/L比率≥97%可作为碘营养状况正常的判定标准(非缺碘地区的标志)。Objective： To explore the feasibility of RIA to test neonatal TSH as the symbol of iodine undeficiency area. Methods： According to the observation data about iodine deficiency disorders （IDD） , using TRFIA to the heel blood collected from neonates 72 hours after born （blood en filter paper） . Results： In tile environment of the state of peopleg iodine nutrition basically conforming to the standard of removing IDD. The percentage of using TRFIA to test TSH in the neonatal blood over 5 mU/L was 2. 57% （426/16, 548）, but 17. 35% using ELISA （1 500/8 644, 2003 year） . Conclusion： It is a good way to test the heel blood collected from neonates 72 hours after born （ filter paper）, the percentage of TSH lower than 5 mU/L is grater than or equal to 97% which can be as the judgment standard of the normal state of iodine nutrition.

关 键 词：时间分辨荧光免疫法(TRFIA) 新生儿 促甲状腺激素(TSH) 碘标志 

分 类 号：R581[医药卫生—内分泌] R722.1[医药卫生—内科学]