中、重度烧伤合并脓毒血症病人血浆组织因子途径抑制物及组织因子变化的研究  

Observation on antigen levels of TFPI and TF in moderate and severe burned patients with sepsis

作　　者：余绍青[1] 闵定宏[2] 郭菲[2] 陈国安[3] 

机构地区：[1]江西医学院第一附属医院干部病房,江西南昌330006 [2]江西医学院第一附属医院烧伤中心,江西南昌330006 [3]江西医学院第一附属医院血液科,江西南昌330006

出　　处：《中国现代医学杂志》2005年第23期3616-3618,共3页China Journal of Modern Medicine

摘　　要：目的观察中、重度烧伤合并脓毒血症患者血浆组织因子途径抑制物(TFPI)、组织因子(TF)含量的变化及其与感染严重程度的关系。方法用酶联免疫吸附法测定TFPI、TF含量。结果与正常对照组比较,中、重度烧伤感染前期病人TFPI、TF抗原含量明显升高(P<0.01);感染后期病人TF抗原含量明显升高(P<0.01),但TFPI抗原含量无统计学意义(P>0.05),与中、重度烧伤感染前期组比较,中、重度烧伤感染后期组TFPI抗原含量减低(P<0.05)。结论中、重度烧伤合并脓毒血症病人血浆中TFPI抗原水平在感染早期明显升高,感染后期下降,其动态监测对判断烧伤合并脓毒血症病人的病情变化有一定指导意义;TF升高可作为判断严重感染的指标之一。[Objective] To investigate the changes of plasma TPFI and TF in the moderate and severe burned patients with sepsis and the relation of TFPI, TF with the infection and its degree. [Method] TFPI and TF antigens were measured by ELISA assay. [Results] Compared with the nonllal reference group, the antigen of TFPI and TF increased significantly in pro-stage group of moderate and severe burn with septis （P 〈0.01）; but there is no statistic difference of TFPI antigen （P 〉0.05） in post-stage group of moderate and severe burned patients with sepsis, and the TF antigen was significantly high （P 〈0.01）; Compared with pro-stage group of moderate and severe bumed patients, the antigen of TFPI decreased significantly （P 〉0.05）, in post-stage group （P 〉0.05）. [Conclusion] The level of TFPI antigen increased significantly in the early stage of infection of moderate and severe burned patients with sepsis, and decreased in the post- stage. Monitoring the levels of TFPI antigen in patients of moderate and severe burn with sepsis has some significance for judging the patients condition; TF may be used as one of indexes to judge severe infection.

关 键 词：组织因子途径抑制物 组织因子 脓毒血症 中 重度烧伤 

分 类 号：R644[医药卫生—外科学] R631.2[医药卫生—临床医学]