壳聚糖-巯基醋酸偶合物的制备及结构分析  

Preparation and characterization of the chitosan-thioglycolic acid conjugates

作　　者：袁干军[1] 黄红谦[1] 陈德梅[1] 张俊清[1] 

机构地区：[1]海南医学院药学系,海南海口571101

出　　处：《中国海洋药物》2005年第6期41-43,共3页Chinese Journal of Marine Drugs

摘　　要：目的制备一种新型生物粘附材料-壳聚糖-巯基醋酸偶合物,并对其结构进行分析。方法以N-羟基丁二酰亚胺(NHS)作催化剂,采用新的合成工艺制备壳聚糖-巯基醋酸偶合物,并测定了偶合物中巯基的含量,同时对偶合物进行了元素分析和红外光谱测定。结果制备得到了巯基含量为1034μmol.g-1的壳聚糖-巯基醋酸偶合物,阐明了该材料的结构特征。结论新的合成工艺可行,材料的结构可用红外光谱来表征。Objective To prepare a new bioadhesive material-chitosan-thioglycolic acid conjugates from chitosan, and analysed the structure moreover. Methods Preparing chitosan-thioglycolic acid conjugates with a new synthesis method under catalytic reaction by NHS , and the contents of thiol groups in the conjugates were determined. Furthermore, elemental analysis and the IR spectrum of the polymer were determined. Results The content of thiol groups in the chitosan-thioglycolic acid conjugates was 1034μmol·g^-1 ,and the structure was elucidated. Conclusion The new synthesis method was feasible, and the structure can be elucidated by IR spectrum.

关 键 词：壳聚糖-巯基醋酸偶合物 合成 红外光谱 

分 类 号：R931.74[医药卫生—生药学] TQ460.6[医药卫生—药学]