海生素制剂对非小细胞肺癌化疗患者生存质量的影响  

Influence of Haishengsu preparation extracted from Tegillarca granosa on life quality in NSCLC patients after chemotherapy

作　　者：李光耀[1] 张成喜 辛艳春 周红娟 张新 李花兰 王春波 陈守国 

机构地区：[1]聊城市人民医院,山东聊城252000 [2]青岛海生肿瘤医院,山东青岛266033

出　　处：《中国海洋药物》2005年第6期49-51,共3页Chinese Journal of Marine Drugs

摘　　要：目的观察泥蚶提取物-海生素注射液对非小细胞肺癌化疗病人生活质量的影响。方法83例非小细胞肺癌患者随机分为两组,观察组42例,对照组41例,观察组和对照组均用MVP(丝裂霉素-硫酸长春地辛-顺铂)方案进行常规化疗。观察组自化疗开始第1天加用海生素2.4mg iv drip,连用15d。每个化疗周期28d,每例化疗2周期以上,比较两组生活质量相关指标。结果观察组胃肠道反应较对照组明显减轻,进食量、体重增加和KPS分值增加均优于对照组;观察组疗效优于对照组。结论在非小细胞肺癌患者MVP方案化疗时加用海生素注射液,可使疗效和生活质量得到明显提高。Objective To investigate the influence of a new marine preparation （Haishengsu） isolated from Tegillarca granosa on NSCLC patients after chemotherapy. Methods Eightythree patients with NSCLC were randomly divided into two groups. Forty-two patients, in the treatment group were received the injection 2.4mg＋0.9%NaCl 250mL, iv. drip from 1 to 15 days while they were received the routine chemotherapy of MVP. Forty-one patients in the control group were received only the chemotherapy of MVP. Twenty-eight days were considered as one treatment cycle and each patient was received two or more consecutive treatment cycles respectively. Results The gastrointestinal tract reactions in treatment group were alleviated obviously with increased food-intake and body weight gain. Moreover the KPS value and the curative effect in treatment group were higher than those in control group. Conclusion Treatment of Haishengsu injection plus MVP chemotherapy improves the curative effect and life quality of the NSCLC patients without marked adverse effects.

关 键 词：海生素 泥蚶 生存质量 非小细胞肺癌 

分 类 号：R931.74[医药卫生—生药学] R979.1[医药卫生—药学]