抗艾滋病药物的研究进展  

The advances of anti-HIV-1 drugs

作　　者：毕毅[1] 徐进宜[1] 吴晓明[1] 

机构地区：[1]中国药科大学药物化学教研室,江苏南京210009

出　　处：《中国现代应用药学》2005年第6期461-465,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目编号30472083

摘　　要：目的了解目前世界上最新上市的抗艾滋病新药以及正在研究中的新化合物。方法通过对大量有代表性的文献进行归纳,介绍了2000年以来上市的抗艾滋病新药以及各类处于临床和临床前研究的化合物。结果发现抗艾滋病药物在近年来有突破性进展,除了传统的蛋白酶抑制剂,逆转录酶抑制剂外,最新发展的融合抑制剂类药物已上市,并且还有很多具有新型作用机制的化合物以及具有抗H IV-1活性的先导天然化合物正处于研究阶段。结论抗艾滋病药物的发展前景广阔。OBJECTIVE The advances of anti-HIV-1 drugs and medication in research were introduced. METHOD A lot of literatures were cited to summarize, as a result, the new anti-HIV-1 drugs from 2000 and the clinical and preclinical compounds were presented. RESULTS There were tremendous progresses in the anti-HIV-1 drugs, including the novel fusion inhibitors, the classical protease inhibitors, reverse transcriptase inhibitors. There were many new compounds including the lead natural products having anti- HIV-1 activity in the research now, which had new mechanisms. CONCLUSION The anti-HIV-1 drugs will have a great develop- mental foreground.

关 键 词：艾滋病 抗人类免疫缺陷病毒 蛋白酶抑制剂 逆转录酶抑制剂 融合抑制剂 

分 类 号：R512.91[医药卫生—内科学]