氟苯尼考在欧洲鳗鲡体内的药物代谢动力学的研究  

Pharmacokinetics of Florfenicol in European eel

作　　者：余培建[1] 翁祖桐[1] 樊海平[1] 俞道进[2] 陈星[2] 

机构地区：[1]福建省淡水水产研究所,福建福州350002 [2]福建农林大学动物科学学院,福建福州350002

出　　处：《福建水产》2005年第4期52-57,共6页Journal of Fujian Fisheries

基　　金：中国水产科学院资助项目(2004年03号)

摘　　要：应用反相高效液相色谱法对口灌和肌肉注射氟苯尼考在欧洲鳗鲡(Anguilla anguilla)体内的代谢规律进行了研究。按100mg.kg-1口灌给药后血浆、肌肉、肝脏、肾脏中氟苯尼考浓度的达峰时间分别为2h、6h、0.5h、1h,以后开始缓慢下降,给药2d后血浆、肌肉、肝脏、肾脏中的氟苯尼考浓度分别为4.209μg.mL-1、0.792μg.g-1、0.493μg.g-1、1.448μg.g-1,给药3d后血浆中的氟苯尼考浓度分别为0.0836μg.mL-1,肌肉、肝脏、肾脏中的氟苯尼考浓度均未检出;按100mg.kg-1肌肉注射给药后血浆中氟苯尼考浓度达峰时间为0.5h,以后开始缓慢下降,给药5d后血浆中的氟苯尼考浓度为0.1151μg.mL-1,给药10d后血浆中的氟苯尼考浓度未检出。口灌氟苯尼考在欧洲鳗鲡体内血浆、肌肉、肝脏、肾脏中分布可用开放性二室模型来描述,口灌给药的血浆、肌肉、肝脏、肾脏中的消除半衰期(T1/2β)分别为27.939h、18.844h、11.83h、36.87h;肌肉注射氟苯尼考在欧洲鳗鲡体内血浆、肌肉、肝脏、肾脏中分布可用开放性一室模型来描述,肌肉注射给药的血浆中的消除半衰期(T1/2β)为37.52h。The metabolic law of florfenieol in European eel was studied by using RP - HPLC. Oral administration with 100mg · kg^- 1, the peak time of blood plasma, muscle, liver and kidney was 2h, 6h, 0. 5h and lh respectively, and then gradually decreased. After drug administration 2d the concentration of florfenicol in blood plasma, muscle, liver and kidney was 4. 209μg ·ml^-1 , 0. 792μg· g^-1, 0. 493μg · g^ -1 and 1. 448μg · g^-1, respectively; after drug administration 3d the concentration of florfenicol in blood plasma was 0. 0836μg · ml^-1 and the concentration of florfenicol in muscle, liver and kidney were undetectable. Intramuscular （i. m. ） according 100mg · kg^-1 , the peak time blood plasma was 0. 5h, and then gradually decreased. After drug administration 5d the concentration of florfenicol in blood plasma was 0. 1151μg · ml^- 1 and was undetectable after drug administration 10d. The distribution of florfenicol by oral administration in organs of European eel was best described by open two -compartment model, the pharmacokinetic parameter of blood plasma, muscle, liver and kidney , T1/2β was 27. 939h, 18. 844h, 11.83h and 36. 87h , respectively. The distribution of florfenicol by i.m. in organs of European eel was best described by open one -compartment model, the pharmacokinetic parameter of blood plasma, T1/2β was 37. 52h.

关 键 词：氟苯尼考 欧洲鳗鲡 药物代谢动力学 

分 类 号：S859.796[农业科学—临床兽医学] S943.223[农业科学—兽医学]