9F系列海洋真菌代谢产物分离纯化及稻瘟霉活性研究  

Isolation of Secondary Metabolites of 9F Series Marine Fungi and Their Bioactivities against Pyricularia oryzae

作　　者：赵玲玲[1] 张惠平[1] 

机构地区：[1]复旦大学药学院天然药物化学教研室,上海200032

出　　处：《天然产物研究与开发》2005年第6期677-680,共4页Natural Product Research and Development

基　　金：国家自然科学基金资助项目(30371680)

摘　　要：自帕劳群岛的3株9F系列海洋真菌中分离得到4个化合物,采用MS,NMR等光谱技术,确定结构分别为trans-dehydrocurvularin(1),terrein(2),paxilline(3)和citreopyrone(4),其对稻瘟霉P2b菌株的最小抑制浓度分别为:10,100,1.56,3.12μg/mL。其中化合物1是首次从海洋真菌中分离得到。Four known metabolites have been isolated from the culture extracts of three 9F series marine fungi derived from Palau Islands. Their structures have been identified by spectral methods as trans-dehydrocurvularin （1）,terrein（2）,paxilline （3） and citreopyrone（4）. The MIC of 1-4 against Pyricularia oryzae P-2b were 10,100,1.56,3.12μg/mL. Compounds 1 were obtained from the cultures of marine fungi for the first time.

关 键 词：海洋真菌 代谢产物 稻瘟霉 

分 类 号：R284[医药卫生—中药学] Q946.91[医药卫生—中医学]