应用均匀设计法对灯盏花素纳米脂质体的处方优化  

Application of uniform design for preparation of Breviscapine Liposomes

作　　者：田维维[1] 刘清飞[1] 罗国安[1] 王义明[1] 

机构地区：[1]清华大学药物研究所,北京100084

出　　处：《中成药》2005年第12期1373-1375,共3页Chinese Traditional Patent Medicine

基　　金：科技部十五攻关项目(2003BA310A03)资助

摘　　要：目的:对灯盏花素纳米脂质体的制备处方进行优化。方法:采用薄膜挤压法制备灯盏花素纳米脂质体,按均匀设计法,以包封率和载药量为考察指标,对实验结果进行最优子集法的二次回归优选处方配比。结果:用胆固醇和卵磷脂来包封的灯盏花素脂质体包封率为69.60%,载药量为29.06%,平均粒径为105.6 nm。结论:用均匀设计优化后的制备处方制得的灯盏花素脂质体,有较高的包封率和载药量。AIM： To optimize the formulation in the preparation of the Breviscapine Liposomes. METHODS： Using film evaporation-extrusion method to prepare Breviscapine Liposomes according to the uniform design, a optimum formulation was established by determining the entrapment efficiency and the ratio of loading drug. RESULTS ： The entrapment efficiency and the ratio of loading drug of Breviscapine Liposomes prepared with cholesterol and lecithin were determined to be 69.60% and 29.06%, respectively. The average diameter is 105.6 nm CONCLUSION： The application of the uniform design is useful to achieve a large entrapment efficiency and ratio of loading drug.

关 键 词：均匀设计 灯盏花素 纳米脂质体 处方优化 

分 类 号：R944[医药卫生—药剂学]