成人乙肝基因疫苗接种效果Meta分析与成人接种的必要性  

Meta-analysis of the Immunization with Hepatitis B Gene Vaccine on Adults and Vaccination Necessity of Adult

作　　者：武桂英[1] 赵新平[1] 赵耐青[1] 龚幼龙[1] 

机构地区：[1]上海复旦大学公共卫生学院卫生统计与社会医学教研室,200032

出　　处：《中国卫生统计》2005年第6期359-361,共3页Chinese Journal of Health Statistics

摘　　要：目的评价成人接种乙肝基因疫苗后的免疫效果。方法文献检索符合本研究分析条件的成人乙肝基因疫苗接种免疫效果论文10篇,5篇为实验对照研究,5篇为平行对照研究,用抗HBs的转阳率作为效果指标;采用Meta分析中的固定效应模型(General Variance-Based法)和随机效应模型(Der Si monian and Laird法)统计方法进行分析。结果实验对照研究论文经Meta分析,公共OR的估计值为2·842,95%的可信区间为(1·329,4·354),实验组和对照组的抗HBs转阳率差别有统计学意义;平行对照研究论文经Meta分析,公共OR的Mantel-Haeszel估计值为0·6592,相应的95%的可信区间为(0·5435,0·7994),男性组和女性组的抗HBs转阳率差别有统计学意义。结论成人接种乙肝基因疫苗的免疫仍有较好效果,加强对中青年人群的乙肝疫苗接种宣传,控制人群HBsAg感染率。Objective To evaluate the immunization affects with hepatitis B gene vaccine on adults. Methods Ten articles about the immunization with hepatitis B gene vaccine on adults have been collected from Internet, in which five were about case-control studies, and other five were parallel-control studies. Adopted anti-HBs positive rates as effect index. Methods of statistics analysis were adopted both the fixed-effets model （General Variance-Based） and the random-effects model （Del Simonian and Laird） in Meta-analysis. Results By meta-analysis, the popular OR（95 % confidence） of control-group is 2. 842 （ 1. 329, 4. 354）, the difference of the anti-HBs positive rate between the control-group and the case-group has statistical significance. Popular OR （95% confidence） of parallel-control is 0.6592（0.5435, 4.354）, the difference of the anti-FIBs positive rate between the conrol-group and the case-group has statistical significance. Popular OR （95% confidence） of parallel-control is 0.6592（0.5435, 0.7994）, the difference of the anti-FIBs positve rate between the male-group and the female group also have statistical significance. Conclusion The government should enhance publilize of hepatitis B vaccination for the middle and yang people, so that HBsAg infectious rate will be controlled in crowd.

关 键 词：乙肝基因疫苗 成人 免疫效果 META分析 

分 类 号：R186[医药卫生—流行病学]