救心胶囊对损伤内皮细胞黏附因子表达的影响  

Influence of Jiuxin Capsule on Expression of Adhesion Factors in Damaged Endothelial Cells

作　　者：金惠民[1] 李培凡[1] 刘村梁 范英昌[2] 

机构地区：[1]天津市医学高等专科学校,天津300052 [2]天津中医学院,天津300193

出　　处：《天津中医药》2005年第6期501-503,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：天津市卫生局资助课题(02042)

摘　　要：[目的]研究救心胶囊对缺氧和低密度脂蛋白(LDL)血管内皮细胞(EC)损伤的保护作用。[方法]采用体外细胞培养技术,制造缺氧和LDL内皮损伤模型。采用免疫组化方法观察救心胶囊对血管内皮黏附分子-1(VCAM-1)和细胞间黏附分子-1(ICAM-1)的影响。[结果]在缺氧或者LDL状态下,内皮细胞黏附分子(VCAM-1,ICAM-1)表达显著增加。救心胶囊可明显地抑制内皮细胞黏附因子的表达率。[结论]救心胶囊对缺氧和LDL造成的内皮细胞有保护作用。[Objective] To study the proective effect of Jiuxin capsule against hypoxia and blood endothelium injury by low density lipoprotein（LDL）. [Methods] Hypoxia and blood endothelium injury were induced in cell culture in vitro. The influence of Jiuxin capsule on adhesion molecule-1（VCAM-1） and intercellular adhesion molecule-1（ICAM-1）in blood endothelium was observed with immunohistochemistry. [Results] The expression of VCAM-1 and ICAM-1 was obviously increased in the hypoxia or LDL state. The Jiuxin capsule may obviously down-regulated this expression . [Conclusion] The Jiuxin capsule may protect the endothelium cell against injury induced by hypoxia and LDL.

关 键 词：救心胶囊 内皮细胞 内皮黏附分子-1 细胞间黏附分子-1 

分 类 号：R285.5[医药卫生—中药学]