珍珠梅提取物对S_(180)荷瘤小鼠肿瘤增长的抑制作用  

Inhibitory effects of Sorbaria sorbifolia aqueous extract on tumor growth of S_ 180 in mice

作　　者：陈丽艳[1] 柳明洙[1] 郑寿焕[2] 张学武[1] 张琚[3] 

机构地区：[1]延边大学基础医学院生物化学与分子生物学教研室 [2]延边大学医院,吉林延吉133000 [3]南开大学医学分子生物学研究所,天津300073

出　　处：《延边大学医学学报》2005年第4期261-264,共4页Journal of Medical Science Yanbian University

摘　　要：[目的]研究珍珠梅提取物对S180荷瘤小鼠的肿瘤增长抑制作用.[方法]取60只小鼠制作S180荷瘤模型,观察给予珍珠梅提取物后小鼠S180荷瘤的增长抑制率、脾脏指数及胸腺指数的变化;应用RT-PCR方法检测肿瘤组织和瘤旁组织中血管内皮生长因子(VEGF)基因的表达率.[结果]珍珠梅提取物对小鼠S180荷瘤的增长有明显的抑制作用,并能显著提高S180荷瘤小鼠的脾脏指数及胸腺指数;VEGFmRNA在珍珠梅提取物大、中剂量组及环磷酰胺组小鼠肿瘤组织中的表达率与对照组相比较均有显著性差异.[结论]珍珠酶提取物改善S180荷瘤小鼠的免疫功能,下调VEGF在肿瘤组织中的表达,抑制肿瘤增长.OBJECTIVE To study the effects of the Sorbaria sorbifolia aqueous extract for the expression of vascular endothelial growth factor （VEGF） in S180 in mice. METHODS The S180 sarcomas was transplanted into 60 of mice. The inhibition ratio of the tumor weight, the spleen index and thymus index were calculated out, and the expression levels of VEGF were assayed with RT-PCR. RESULTS The aqueous extract of the Sorbaria sorbifolia could increase the levels of inhibition ratio of tumor weight and the spleen index and thymus index in mice and markedly downregulate the expression of VEGF gene with compared to the control group CONCLUSION The aqueous extract of the Sorbaria sorbifolia can improve immune function, and inhibite the expression of VEGF and tumor growth.

关 键 词：肉瘤 植物 药用 内皮生长因子 

分 类 号：R285.5[医药卫生—中药学]