蛇葡萄素对家兔离体子宫平滑肌收缩性能的影响  

Effect of Ampelopsin on the Contraction of Isolated Uterus of Rabbits Induced by Some Mediators

作　　者：朱慧玲[1] 胡春菊[2] 黄先菊[1] 张昊[1] 

机构地区：[1]长江大学医学院,湖北荆州434000 [2]韩山师范学院,广东潮州521041

出　　处：《长江大学学报（自然科学版）》2005年第12期352-354,331,共3页Journal of Yangtze University(Natural Science Edition)

摘　　要：目的:探讨蛇葡萄素(Ampeloptin,AP)对多种物质诱导的子宫平滑肌收缩的抑制作用。方法:离体子宫平滑肌实验方法。结果:AP能够显著抑制子宫平滑肌自律性及氯化钾、缩宫素诱导的家兔离体子宫平滑肌收缩反应。AP对高K+除极化后Ca2+诱导的子宫平滑肌收缩有松弛作用。AP对缩宫素所致子宫的依内钙收缩及CaCl2引起的依外钙收缩均有明显抑制作用,且对前者抑制作用更为明显。结论:AP对家兔离体子宫平滑肌有较好的松弛作用。Objective:To observe the antagonism of Ampelopsin(AP) on the contraction of isolated uterus of rabbits induced by some mediators.Methods:In vitro experimental method of smooth muscle was used.Results:AP and Ver can inhibit the contractile rhythms of uterus and contraction of isolated uterus of rabbits induced by KCL and oxytocin.AP can inhibit the contraction of isolated uterus induced by Ca^(2+) after the uterus was depolarized by high concentration of K^+.And it can also inhibit intracellular Ca^(2+)-dependent contraction induced by oxytocin and extra cellular Ca^(2+)-dependent contraction induced by CaCl_2 respectively,especially the former one.Conclusion:AP has significant relaxing effect on the contraction of isolated uterus.

关 键 词：平滑肌 子宫 蛇葡萄素 缩宫素 氯化钾 氯化钙 维拉帕米 

分 类 号：R965[医药卫生—药理学]