广州某院产超广谱β-内酰胺酶菌株的监测分析  

Investigation of producing ESBL bacteria in a hospital in Guangzhou

作　　者：白英明[1] 赖福才[2] 

机构地区：[1]南方医科大学南校区医学检验教研室,广东省广州市510315 [2]南方医科大学南方医院,广东省广州市510515

出　　处：《第一军医大学分校学报》2005年第2期110-113,共4页Journal of Branch Campus of the First Military Medical University

基　　金：广州市科委重点医攻关项目(2000-Z-027-01)

摘　　要：目的了解产超广谱β-内酰胺酶(ESBLs)细菌在本院分离及分布情况,以利于对ESBLs细菌的监控和治疗.方法双纸片协同实验及确证实验,对2001-09～2003-07期间,该院592株革兰阴性杆菌检测超广谱β-内酰胺酶(Extended-Spectrum-Lactamases,简称ESBLs).结果肺炎克雷伯菌ESBLs携带率41.596(39/94)、大肠埃希菌ESBLs携带率36.0%(72/200)、阴沟肠杆菌ESBLs携带率29.4%(10/34)、嗜麦芽窄食单胞菌ESBLs携带率64.3%(36/56),另外发现4株产ESBLs酶的铜绿假单胞菌.结论该院产ESBLs菌流行情况严重.临床细菌实验室有必要建立一种可行的检测方法,以利于对产ESBLs菌的监控,特别是对医院产ESBls菌高分离率的病房应加以监控,指导临床合理选用抗生素,降低由产ESBLs菌引起医院感染爆发流行的可能性.Objetive To investigate the distribution of producing extended - spectrum β - actamase （ESBLs） bacteria in the hospital,for better control and treatment. Methods Poducing ESBLs bacteria were detected by the double -sheets synergic method and disc diffusion confirmatory test from 592 bacterial straing which were Collected from September of 2001 to July of 2003. Results Among 94 strains of Klebsiella Pneumoniase,200 strains of Escherichia coli, 34 strains of Enterobacter cloasas , the positive rates of producing ESBLs bacteria were 41.5%, 36%, 29.40/d respectively. At the same time 4 producing ESBLs strains were found in 147 strains of Pseudomenas aerugionsa. Condusion The infection of producing ESBLs bacteria bacteria was severe in the hospital. It is necessory for clinic germs laboratories to build up a kind of feasible method to monitor the producing ESBLs bacteria, expecially in the wards with high producing ESBLs bacteria positive rate, which could guide the doctors to select proper antibiotics and then lower the possibility of epideic out break of producing ESBLs bacteria infection in the hospitals.

关 键 词：超广谱Β-内酰胺酶 肺炎克雷伯菌 大肠埃希菌 嗜麦芽窄食单胞菌 

分 类 号：R978.1[医药卫生—药品] R978.11[医药卫生—药学]