女性吸毒者戊型肝炎病毒感染与IL-8的关系研究  

The Study of HEV Infection and its Relationship with IL-8

作　　者：王秀[1] 李登清[2] 黄民主[3] 谢妮[1] 杜国有[1] 

机构地区：[1]广东省深圳市第二人民医院检验科,深圳518000 [2]中南大学医学技术与情报学院检验系 [3]中南大学公共卫生学院,长沙410000

出　　处：《现代临床医学生物工程学杂志》2005年第5期410-411,共2页Journal of Modern Clinical Medical Bioengineering

摘　　要：目的探讨女性吸毒者戊型肝炎病毒感染与白细胞介素-8的关系.方法采用横断面研究,以某戒毒所304名女性吸毒者为调查对象,取5ml血标本.用ELISA法测定其血清中戊型肝炎病毒的IgG抗体(抗HEV IgG)及白细胞介素-8(IL-8)的含量,进行比较分析.结果调查对象大部分为年轻、未婚、文化程度偏低,以下岗及无业人员为主.304份标本中抗-HEV IgG阳性者19例,HEV感染率为6.3%.抗-HEV IgG阳性吸毒者IL-8为(0.292±0.055)μg/L,高于HEV阴性的吸毒组IL-8(0.249±0.020)μg/L(t=2.965,p<0.01);正常健康人员IL-8为(0.235±0.013)μg/L,低于抗-HEV IgG阳性吸毒组均值(t=4.447,p<0.01).结论女性吸毒人群是戊型肝炎病毒感染的高危人群.女性吸毒者抗-HEV IgG阳性组IL-8含量显著高于阴性组及正常健康组.Objective To estimate the relationship between HEV infection with IL- 8. Methods 304 female drug abusers were selected by cross - sectional survey from Zhuzhou Narcotic Abstention Institute. Draw 5ml blood. The anti - HEV IgG and the con- centration of the IL - 8 were tested by ELISA. All data were analyzed by SPSS 11.0. Results Most of the subjects were young, unmarried, lower educated and unemployed. There were 19 subjects＇ anti- HEV IgG positive among 304. The overall infection rate of HEV was 6.25 % . The IL- 8 concentration in anti - HEV IgG positive drug users was（O. 292 ± 0.055 ）μg/L, while in HEV negative drug users was （0.249 ±0.020）μg/L （p 〈 0.01）. The IL- 8 concentration of the normal healthy control was （0.235 ± 0.013）μg/ L （p 〈0. 01 vs HEV positive）. The means of the tow groups were performed t - test, t = 4. 447, p 〈 0. 01. Conclusions Female drug users were a highly risk group of HEV infection. The concentration of IL - 8 in anti - HEV IgG positive female drug users was statistically significant higher than the HEV negative female drug users and normal healthy control.

关 键 词：戊型肝炎 感染 女性 吸毒人群 白细胞介素-8 

分 类 号：R512.65[医药卫生—内科学]