基质金属蛋白酶-23、及其组织抑制剂TIMP-1在子宫内膜异位症中的表达  

The expression of matrix metallop roteinase-2,3 and tissue inhibitor of metalloproteinase-1 in endometriosis

作　　者：刘海英[1] 于晓艳[1] 傅松滨[2] 关咏梅[1] 

机构地区：[1]哈尔滨医科大学附属第二医院,哈尔滨150086 [2]哈尔滨医科大学遗传教研室

出　　处：《中国优生与遗传杂志》2005年第12期19-20,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨基质金属蛋白酶(MMP-2、MMP-3)及其抑制剂(TIMP-1)在子宫内膜异位症发生及发展中的作用。方法采用免疫组化SP法分别测定MMP-2、MMP-3、TIMP-1在卵巢子宫内膜异位症异位内膜60例(A组),子宫腺肌症异位内膜40例(B组),子宫肌瘤子宫内膜30例(对照组C)的表达强度。结果A、B组中MMP-2、MMP-3的表达强度明显高于对照组(P<0.05)而TIMP-1的表达明显低于对照组(P<0.05);A、B组间MMP-2、MMP-3、TIMP-1的表达无明显差异(P>0.05)。结论在子宫内膜异位症中MMP-2、MMP-3的过度表达及TIMP-1的低表达可能与内异症的发生与发展有关。Objective： To investigate the role of matrix metalloproteinase- 2,3 and tissue inhibitor of metalloproteinase- 1 in the pathogenesis endometriosis. Methods： Immtmohistoehemical method（SP） was employed to detect the expression of MMP- 2,3 and TIMP- 1 in ectopic endometriotic tissue from women with endometriosis （60 cases） and with adenomyesis （40 cases） and the normal controls （30 cases）. Results： The expressions of MMP - 2, MMP - 3 in ectopic endometriotic tissue were higher than those of uterine endometrium from women without endometrosis（P〈 0.05）. The expression of TIMP - 1 in ectopic endometriotic tissue were lower than those of uterine endometrium from women without endometrosis（ P 〈 0.05）. The expressions of MMP- 2, MMP - 3, TIMP- 1 were no obvious difference between the ectopic endometriotic tissue from women with endometriosis and with adenomyosis（ P 〉 0.05）. Conclusion： The increased expression of MMP- 2,3 and decrease expression of TIMP - 1 in the eetopic endometriotic tissue contributes to the pathogenesis of endometriosis.

关 键 词：子宫内膜异位症 基质金属蛋白酶 基质金属蛋白酶组织抑制剂 基因表达 

分 类 号：R711.71[医药卫生—妇产科学]