儿童抗癫痫药高敏综合征6例临床报告及文献复习  

To report 6 cases of antiepileptic drug hypersensitive syndrome of children and to review literature and to summarize its clinical characteristics

作　　者：杨斌[1] 李汉广[1] 王守星[1] 王成月[1] 张志民[1] 

机构地区：[1]安徽省立儿童医院神经内科,合肥230054

出　　处：《中国优生与遗传杂志》2005年第12期109-110,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的总结儿童抗癫痫药高敏综合征(AHS)的临床特点。方法报告6例儿童抗癫痫药高敏综合征及复习国内外文献,总结儿童AHS的临床特点。结果儿童AHS患者均有发热、皮疹及内脏损害,部分患者的皮疹表现为Stevens-Johson综合征(SJS)、中毒性表皮松解症(TEN),立即停用致病药物及应用糖皮质激素是治疗的关键。结论芳香族抗癫痫药(苯妥英钠、苯巴比妥及卡马西平)能导致儿童AHS。Objective：The purpose of this study was to investigate the clinical charateristics of antiepileptic drug hypersensitive syndrome （AHS） of children Methods ： To report 6 cases of AHS of children and to review literature and to summarize its clinical characteristics. Results ： AHS of children is characterised by fever, skin rashes and involvement of the internal organs. Stevens - Job.son syndrome （SJS） and toxic epidermal necrolysis （TEN） were observed in some patients. It is important that treatment of these subjects involved stopping administration of the causative drugs, and administered treatment of predrtisolone. Conclusion： AHS of children is most freguently associated with aromatic antiepileptic drugs, including phenytion, phenobarbital and carbamazepine.

关 键 词：儿童 抗癫痫药高敏综合征 苯妥英钠 卡马西平 苯巴比妥 

分 类 号：R725.9[医药卫生—儿科]