温敏在体凝胶给药系统的研究与应用  

Research and Application of Temperature-sensitive in Situ Gel Drug Delivery Systems

作　　者：胡雄林[1] 周建平[1] 

机构地区：[1]中国药科大学药剂教研室,江苏南京210009

出　　处：《药学进展》2005年第12期535-540,共6页Progress in Pharmaceutical Sciences

摘　　要：综述N-异丙基丙烯酰胺类聚合物、聚氧乙烯-聚氧丙烯共聚物、聚氧乙烯-聚乳酸羟基乙酸共聚物和多糖类衍生物等温敏聚合物的性质、特点、胶凝机制及在温敏在体凝胶给药系统中的应用进展。温敏在体凝胶作为一种智能水凝胶,可用作药物缓、控释和靶向输送的有效载体。The characteristics, gelling mechanism and application in temperature-sensitive in situ gel drag delivery system of poly （N-isopropylacrylamide）, poly （ oxyethylene- b-oxypropylene ）, poly （ oxyethylene -D, L-lactic acid- co -glycollic acid） copolymers and polysaccharides were reviewed. Temperature-sensitive in situ gel, a kind of smart hydrogel, could be used as a good carrier for sustained, controlled and targeting drug release.

关 键 词：温敏在体凝胶 聚合物 给药系统 控释 靶向释药 

分 类 号：R94[医药卫生—药剂学]